Sep 26, 2023 · Here we show that a natural product P57 promptly induces hypothermia and decreases energy expenditure in mice. Mechanistically, P57 inhibits the kinase activity of pyridoxal kinase (PDXK), a...

We have now established mice in which the p57 gene is conditionally disrupted in the brain. Acute inactivation of p57 resulted in massive apoptosis predominantly in Pax2-positive interneuron precursors of the developing cerebellar primordium as …

Previous studies using p57 knockout mice reported an increase in apoptosis and altered differentiation during mouse development [63, 64]. It is plausible, therefore, to conclude that JNK/SAPK inhibition could be an important mechanism by which p57 exerts its functions not only on proliferation but also on cell death.

Sep 2, 2011 · To ablate the maternal p57 allele only in the hematopoietic system, we crossed female p57 +/F mice with male mice harboring a Cre transgene under the control of the promoter for the myxovirus resistance 1 (Mx1) gene.

Through inhibition of CDKs, p57 negatively regulates the cell division cycle, acting as a putative tumor suppressor. 1, 2 Unlike other CDK inhibitors, p57 plays a critical role during embryonic development, and the knockout of p57 in mice (p57 KO) results in perinatal lethality caused by numerous developmental anomalies. 3, 4 Some phenotypes of ...

Mar 19, 2025 · One molecule that has gained attention in this field is P57, a protein with significant implications for metabolic control and energy balance. Research suggests that P57 plays a crucial role in coordinating physiological responses related …

Herein, we discovered that p57 Kip2 (p57), a cyclin-dependent kinase inhibitor canonically inhibiting cell proliferation, played a role in suppressing the pluripotency state of mouse ESCs (mESCs). p57 knockdown significantly stimulated the expressions of core pluripotency factors NANOG, OCT4, and SOX2, while p57 overexpression inhibited the ...

The gene encoding p57 undergoes genomic imprinting, and impairment of the regulation of p57 expression results in various developmental anomalies in humans and mice. We now show that p57 is expressed predominantly in the subcommissural organ and cerebellar interneurons in the mouse brain and that mice with brain-specific deletion of the p57 ...

Sep 2, 2011 · Moreover, the HSC abnormalities of p57-deficient mice were corrected by knocking in the p27 gene at the p57 locus. Our results therefore suggest that, among Cip/Kip family CDK inhibitors, p57 plays a predominant role in the quiescence and maintenance of adult HSCs.

Mar 31, 2009 · Although p27 and p57 are structurally related cyclin-dependent kinase inhibitors (CKIs), and are thought to perform similar functions, p27 knockout (p27 (KO)) and p57 (KO) mice show distinct phenotypes.