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CIgG is secreted by tumor cells and functions as an activator of integrin α6β4 on tumor cells (autocrine), siglecs on T cells, FcγRI on NK cells, and FcγRIIa on platelets (all paracrine). It drives tumorigenesis, immunosuppression, and platelet activation.

Mar 18, 2025 · Cigarette, paper-wrapped roll of finely cut tobacco for smoking; modern cigarette tobacco is usually of a milder type than cigar tobacco. After data indicated that cigarette-smoking is related to disease and death, governments began enacting regulations to limit smoking. Globally, cigarette consumption rates have fallen throughout the 21st century.

In this study, cancer-derived immunoglobulin G (CIgG) is found to be induced after ADT, identifying CIgG as a potential CRPC driver gene. Methods: The expression of CIgG and its clinical significance in PCa tissue was analyzed by The Cancer Genome Atlas database and immunohistochemistry.

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There are two types of non-combusted cigarettes currently allowed to be sold in the U.S. One product type, which has been on the U.S. market at various times since the 1990s, uses a carbon tip ...

Mar 12, 2019 · CIgG may be involved in colorectal cancer invasion and metastasis through interacting with E-cadherin. Conclusions: CIgG is a potential human oncogene in colorectal cancer and that it has potential for application as a novel target in targeted therapy and a marker for prognostic evaluation.