The US Food and Drug Administration announced Thursday that it will be phasing out a requirement that monoclonal antibodies and other drugs be tested on animals, saying in a news release that ...

But promising results from a recent clinical trial suggest that broadly neutralizing antibody therapy (bNAbs) may be able to accomplish the next best thing. Data from the trial—a collaboration ...

Attribution (BY): Credit must be given to the creator. Immunoreagents, most commonly antibodies, are integral components of lateral flow immunoassays. However, the use of antibodies comes with ...

Additionally, the ER stress and apoptosis indices were investigated by quantitative real-time PCR (qRT-PCR), Western blotting, and immunofluorescence (IF ... was carried out at 4°C with primary ...

In the human heart, we first detected lipid overload accompanied by a reduction of XBP1 (X-box binding protein 1) under metabolic stress. Thereafter, a decrease in EDEM2 was confirmed in human and ...

Note that IgG heavy chain does not appear in panel B because the DNAJC7 antibody was covalently linked to immunoprecipitation ... (A) Schematic of iPSC differentiation into lower motor neurons ...

Different types of antibodies are produced by your immune system. These five antibodies help fight disease by detecting viruses, bacteria, and other pathogens (disease-causing microorganisms) and ...

In recent years, antibody-drug conjugates (ADCs ... carfilzomib can induce the expression of CRT through the endoplasmic reticulum stress pathway IRE1-XBP1. As an effective means to enhance the ...

Treatment of mice with tunicamycin (Tm) (an ER stress inducer) increased PHLDA3 expression in the liver. X box-binding protein-1 (Xbp1) was newly identified as a transcription factor responsible for ...