Who is the favorite to win 2025 NCAA Tournament entering Final Four games? Check out national championship odds for Auburn, Florida, Houston, Duke.

All four No. 1 seeds advanced to the men’s Final Four in San Antonio. Does that mean the NCAA tournament is saving its best for last?

According to DraftKings, Duke (+110) has the best odds to win the title entering the Final Four. Florida (+250), Houston (+400) and Auburn (+475) round out the rest of the Final Four teams. Gambling problem? Call (877-8-HOPENY) or text HOPENY (467369).

NCAA Final Four field is now set following a Sunday where No. 1 seeds Houston and Auburn made it a clean sweep with four No. 1s reaching the Final Four for the first time since 2008 and second time ever.

For the 18th time in program history and the first time under head coach Jon Scheyer, the top-seeded Duke Blue Devils will play in the Final Four after they ousted No. 2 Alabama on Saturday night.

Madness odds for Houston Cougars vs Duke Blue Devils Final Four NCAA Tournament game, including point spread, moneyline, over/under for betting.

The SportsLine Projection Model has revealed its Houston Cougars vs. Duke Blue Devils picks for the Final Four of the 2025 NCAA Tournament on Saturday

Oddly enough, the Alamodome was also the venue the only other time all four No. 1 seeds made the Final Four. In 2008, Kansas toppled Memphis in overtime to win Bill Self’s first national title, tying the game in the final seconds of regulation with a Mario Chalmers 3-pointer after Derrick Rose missed a potential clinching free throw.

While the UCLA men’s basketball program is one of the more storied ones in sport, the women are just trying to carve out a legacy of their own. They took that f