In a US study, patients with severe eosinophilic esophagitis (EoE) by Index of Severity for EoE had poor responses to topical corticosteroid therapy.

Inflammatory markers play a pivotal role in phenotyping asthma, assessing risks, and tailoring personalised therapeutic strategies, particularly in asthma associated with allergic sensitisation ...

Lower airway inflammation and asthma control are worse in patients ... The current framework suggests distinguishing between type 2 (eosinophilic) and non-type 2 inflammatory responses (32). While it ...

Itepekimab is a fully human monoclonal antibody that binds to and inhibits interleukin-33 (IL-33), an initiator and amplifier of broad inflammation in COPD. Itepekimab is currently under clinical ...

The effects of BTLA agonist treatment were assessed on airway hyperreactivity and lung inflammation. Discussion: Our findings establish BXD75 mice as a model for steroid-resistant asthma and ...

First approved in 2015 for severe asthma with an eosinophilic phenotype in the US, mepolizumab is a monoclonal antibody that targets and binds to interleukin-5 (IL-5), a key messenger protein ...