RNA splicing is a modification of the nascent pre-messenger RNA (pre-mRNA) transcript in which introns are removed and exons are joined prior to translation. For many eukaryotic introns ...

In silico tools for splicing defect prediction have a key role to assess the impact of variants of uncertain significance. Our aim was to evaluate the performance of a set of commonly used splicing in ...

The complexity of eukaryotic DNA, with its long-range interactions ... The model demonstrated sensitivity to mutations in start codons, splice sites, and conserved genomic regions, with ...

RNA splicing is a cellular process that is critical for gene expression. After genes are copied from DNA into messenger RNA, portions of the RNA that don't code for proteins, called introns ...

Biologists have discovered a new type of RNA-splicing regulation that helps to determine which protein-coding exons will be included in messenger RNA transcripts. RNA splicing is a cellular ...

Eukaryotes, especially, are typically underrepresented and have low coverage in complex metagenomic datasets from sediments. In this study, we evaluate the potential of eukaryotic gene annotation in ...

Karen is a science journalism intern at The Scientist. Her PhD and post doctoral research was in molecular biology. She has previously written for Science, Creative Nonfiction, and Altasea. View Full ...

Alternative splicing plays a pivotal role in defining cell phenotypes and physiology in multicellular eukaryotes, often distinguishing between cell types more accurately than gene expression. 1 During ...

In contrast to Bacteria, which use undecaprenol as the N-glycan lipid carrier, Archaea assemble the N-glycan on dolichol (Dol) identical to Eukaryotes. Archaea also display unique N-glycosylation ...

RNA splicing is an essential part of eukaryotic gene expression. Although the mechanism of splicing has been extensively studied in vitro, in vivo kinetics for the two-step splicing reaction remain ...