RNA splicing is a modification of the nascent pre-messenger RNA (pre-mRNA) transcript in which introns are removed and exons are joined prior to translation. For many eukaryotic introns ...

In higher eukaryotes, a vast variety of RNAs are transcribed from genomic DNAs. The transcribed RNAs are subjected to RNA splicing in order to produce mRNAs and non-coding RNAs. Splicing includes ...

As an independent investigator at the National Institutes of Health (NIH)—where she set up shop in 1976—Gottesman made major contributions in the field of prokaryotic gene regulation, uncovering key ...

Five scientists won this year’s Breakthrough Prize in Life Sciences for their work on GLP-1 and the development of drugs for diabetes and obesity.

Two molecular control factors play a decisive role in what is known as splicing, the cutting and assembly of mature messenger RNA—a prerequisite for protein synthesis in the cell. The poorly ...

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