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Biologists discover a new type of control over RNA splicing
In the first step of spliceosome assembly, an snRNA molecule known as U1 snRNA binds to the 5' splice site at the beginning of the intron. Until now, it had been thought that the binding strength ...
AZoLifeSciences on MSN1mon
LUC7 Proteins Play Key Role in RNA Splicing Control
In the first step of spliceosome assembly, an snRNA molecule known as U1 snRNA binds to the 5' splice site at the beginning ...
Phys.org3d
Quality assurance in the cell: Preventing defective protein blueprints
Splicing is catalyzed by a large molecular machine. This spliceosome is made up of variety of protein and RNA components, and for each splicing process, it is reassembled at the sites where an ...
The Scientist1y
Molecular Biology
This process is mediated by the spliceosome, a cellular complex composed of both RNA ... "Early studies demonstrated that one of the RNAs--the small nuclear RNA (snRNA) U1--base-pairs with the 5_ ...