Lipids in cell membranes regulate the activity of a cancer-linked protein, cell biologists at RIKEN have discovered. This ...

Focal cortical dysplasia (FCD) type 2 is a congenital malformation of the cerebral cortex that is often associated with difficult-to-treat epilepsy. In the affected areas, nerve cells and their layer ...

Moreover, the expression levels of 606 genes appeared to be significantly modulated by miltirone via RNA-seq analyses, and PI3K/AKT signaling pathway was found to refer to miltirone activity.

Furthermore, since RhoA deactivation is critical for successful abscission, any disruption in this signaling pathway could compromise the final stages of cytokinesis. While we do not directly observe ...

In this long-term work, the researchers demonstrated that the NOTCH signaling pathway, conserved throughout the evolution of all multicellular organisms, plays an essential role in the ...

More information: Arjit Nigam et al, Platelet spreading and clot retraction are regulated by 2 distinct αIIbβ3 outside-in signaling pathways, The Journal of Pharmacology and Experimental ...

Conclusions: S100A9 is a significant promoter of M2-like macrophage-induced fibrosis in CP via the TAOK3-JNK signaling pathway. Cobamamide and daptomycin, targeted inhibitors of the S100A9-TAOK3 ...

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China School of Environment, Hangzhou ...