A type of aggressive, treatment-resistant brain tumor has a distinct population of immune cells that support its growth, ...

Brain metastases are one of the most severe complications of melanoma, the most aggressive type of skin cancer. Researchers at the Institute for Neurosciences (IN), a joint center of the Spanish ...

Announcing a new publication for Acta Materia Medica journal. Single-cell RNA sequencing (scRNA-seq) data from published ...

Rapamycin is mTORC1 inhibitor, but long-term exposure to rapamycin (>18 hours) could also inhibit mTORC2. RhoA signaling pathway is regulated through the mTORC2 pathway; thus we hypothesized that long ...

By inducing a non-canonical RhoA/ROCK signaling pathway, IL-1beta inhibits the ability of SARS-CoV-2 infected cells to fuse with uninfected cells and produce syncytia. Convincing evidence underlies ...

7 refine our understanding of the signaling effects of oncogenic KRAS. Rather than activating multiple effectors, mutant KRAS signals preferentially through the RAF–MEK–ERK pathway ...

Arsenal are closing in on a deal to sign Real Sociedad midfielder Martin Zubimendi in the summer, Sky Sports News understands - but the Gunners are working hard for a new striker this month. It is ...

The emerging era of personalised medicine means new, pragmatic approaches will focus increasingly on real-world evidence. In this new environment, pharma must be prepared to work collaboratively ...

Department of Agronomy, Ecological Sciences & Engineering Interdisciplinary Graduate Program, Purdue University, 915 Mitch Daniels Blvd, West Lafayette, Indiana 47907, United States Environmental & ...

We hypothesized that the mechanical stretch caused by UPLS can be sensed by PECAM-1 in the lungs, leading to VILI via the Src/STAT3 and pyroptosis pathway. Results: UPLS activated PECAM-1, Src/STAT3 ...