RNA splicing is a modification of the nascent pre ... but there are also self-splicing introns. Spliceosomal snRNP core assembly typically requires chaperones such as the SMN complex.

Heidelberg biochemists and structural biologists from Shanghai unravel the roles of two key regulatory factors in mRNA ...

Scientists at Oak Ridge National Laboratory have developed the first-ever method of detecting ribonucleic acid, or RNA, ...

Scientists found that pseudouridine helps small RNAs pass on traits and avoid immune detection, offering clues for future RNA ...

Alternative RNA splicing is like a movie editor cutting and rearranging scenes from the same footage to create different versions of a film. By selecting which scenes to keep and which to leave out, ...

This study shows that RNA decay rather than the presence of premature termination codons triggers a TA-like response.

Researchers have discovered that cancer cells suppress 'poison exons' -- genetic elements that act as an off switch for protein production -- in a key gene called TRA2 , promoting tumor growth.

as it offers both a refined predictive model and a new tool to designing RNA sequences for targeted splicing outcomes. Alternative splicing (AS) of pre-mRNA plays a crucial role in tissue-specific ...

The authors propose a transformer-based model for the prediction of condition - or tissue-specific alternative splicing and demonstrate its utility in the design of RNAs with desired splicing outcomes ...

1State Key Laboratory of Molecular Oncology, SXMU-Tsinghua Collaborative Innovation Center for Frontier Medicine, School of Basic Medical Sciences, Tsinghua University, Beijing, China. Search for ...

P-TEFb and the protein components of 7SK snRNP, such as HEXIM1 and MePCE are believed to be essential for LARP7 to regulate transcription. We subsequently evaluated the binding affinity of LARP7 ...