While BMP-2 can effectively induce chondrogenic differentiation and inhibit osteogenic differentiation of MSCs, it can also initiate hypertrophic differentiation and endochondral ossification.

Human extracellular matrices can be edited in their composition using the CRISPR/Cas9 system, leading to materials exhibiting tailored regenerative capacities.

BMP2 induced MSC chondrogenic differentiation and triggered endochondral ossification. Sox9 promoted chondrogenic differentiation and inhibited BMP2-induced endochondral ossification. Notch1 ...

Researchers have identified in a new study that oral infigratinib, an FGFR1-3 selective tyrosine kinase inhibitor, improves ...

Cartilage has limited repair capacity once damaged. Endochondral ossification is hard to recapitulate with human cells. Here, the authors generated SOX9+ sclerotomal progenitors from hPSCs ...

Endochondral ossification is hard to recapitulate with human cells. Here, the authors generated SOX9+ sclerotomal progenitors from hPSCs, modeling key developmental stages of bone development and ...

While BMP-2 can effectively induce chondrogenic differentiation and inhibit osteogenic differentiation of MSCs, it can also initiate hypertrophic differentiation and endochondral ossification.

A study analyzing lab mice flown into space for 37 days may help determine what will have happened to Wilmore and Suni ...

uk-erlangen.de Background Osteophyte formation is a common phenomenon in arthritis. Bone formation by endochondral ossification is considered a key pathophysiological process in the formation of ...

MicroRNAs (miRNAs) are critical regulators of the skeleton. In the growth plate, these small non-coding RNAs modulate gene networks that drive key stages of chondrogenesis, including proliferation, ...

Complete displacement of the epiphysis although rare, can occur. This occurs in children with systemic disorders affecting endochondral ossification patterns in metaphysis. In contrast with type 1A ...