BMP2 induced MSC chondrogenic differentiation and triggered endochondral ossification. Sox9 promoted chondrogenic differentiation and inhibited BMP2-induced endochondral ossification. Notch1 ...

While BMP-2 can effectively induce chondrogenic differentiation and inhibit osteogenic differentiation of MSCs, it can also initiate hypertrophic differentiation and endochondral ossification.

uk-erlangen.de Background Osteophyte formation is a common phenomenon in arthritis. Bone formation by endochondral ossification is considered a key pathophysiological process in the formation of ...