Researchers have found a potential new way to slow the progression of lung fibrosis and other fibrotic diseases by inhibiting the expression or function of Piezo2, a receptor that senses mechanical ...

Ten years of substantial work by Université de Montréal immunologist Nathalie Labrecque's team at the Montreal Clinical ...

The Strategic Choice of UCLA Inter Milan, a historic powerhouse in Italy's Serie A, has gained a reputation for its strategic approach to competition preparation. By choosing UCLA as their training ...

The five-year-old Software Acquisition Pathway (SWP) policy authorized by the fiscal year 2020 National Defense Authorization Act is being reemphasized. A new memo from the Secretary of Defense Pete ...

(D) Pathway analysis of gene clusters in panel C ... stimulated with TNF and selective agonists of PGE2 receptors EP2 and EP4 that signal predominantly via cAMP. EP2 agonist = butaprost (10 μM); EP4 ...

and exchange protein directly activated by cAMP (EPAC) (15, 28, 29). Both of these activated proteins are involved in activation of the downstream effector extracellular signal-regulated kinase (ERK).

Essex pair Jodi Grewcock and Grace Scrivens, Surrey's Emma Jones and Alexa Stonehouse and Lancashire's Grace Potts are the only members of the squad without a senior international cap ...

CD8+ T cells accumulate in atherosclerotic plaques. LMU researchers identify a crucial signaling pathway - with therapeutic potential. Atherosclerosis is the most common cause of life-threatening ...

In conclusion, Zhang et al uncovered novel autocrine mechanisms that couple GsPCR activation to e[ATP] and e[cAMP]-mediated signaling to regulate cardiomyocyte survival. Although technically ...