BOSTON - Mass General Brigham, the largest health care system in Massachusetts, announced layoffs Monday that will affect hundreds of workers, citing a $250 million projected budget gap.

Facing rising costs and hoping to make its sprawling network more efficient, the state’s largest private employer aims to cut payroll costs by over $200 million.

Mass General Brigham attributed the layoffs to an expected budget shortfall of $250 billion over the next two years.

Mass General Brigham announced layoffs for hundreds of administrative and management employees on Monday in anticipation of a $250 million budget gap, an unprecedented decision for Massachusetts’ largest private employer.

According to the report, it marks the largest layoff in the history of the organization — Massachusetts’ largest private employer. Mass General Brigham declined to provide the amount of employees affected, but plans to save at least $200 million annually as a result, according to the report.

The layoffs could potentially impact employees at 12 hospitals under the MGB umbrella: While executives say the sweeping cuts are aimed at management and administrative-level employees with no impact on front-line workers, Boston University School of Public Health’s David Rosenbloom suspects the changes could reach patients.

Mass General Brigham announces layoffs to address a $250 million budget deficit, focusing on non-clinical roles, aiming for efficiency and a resilient future.

Nonprofit giant Mass General Brigham (MGB) will be laying off numerous non-clinical employees to close major budget shortfalls. | The major nonprofit system declined to put a number on the cuts and consolidations,

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