AHA/ASA Journals3d
Myeloid Fatty Acid Metabolism Activates Neighboring Hematopoietic Stem Cells to Promote Heart Failure With Preserved Ejection Fraction
BACKGROUND: Despite the high morbidity and mortality of heart failure with preserved ejection fraction (HFpEF), treatment ...
pharmaphorum3d
Trial finds benefit for GLP-1 agonist in Parkinson’s
A small study of Sanofi’s lixisenatide has suggested that the GLP-1 agonist could slow down the progression of Parkinson’s disease, pointing to another potential use for the fast-growing drug ...
thecardiologyadvisor.com5d
GLP-1 Receptor Agonists May Have Broader Range of Benefits, Risks
Kidney stones are among the possible risks of GLP-1 use that were not previously known. Glucagon-like peptide 1 receptor agonists (GLP-1RAs) may have a wider range of benefits and risks than what the ...
ahajournals.org5d
Combined Loss of Obsc and Obsl1 in Murine Hearts Results in Diastolic Dysfunction, Altered Metabolism, and Deregulated Mitophagy
Muscle proteins of the obscurin protein family play important roles in sarcomere organization and sarcoplasmic reticulum and T-tubule architecture and function. However, their precise molecular ...
eLife5d
Targeting IRE1α improves insulin sensitivity and thermogenesis and suppresses metabolically active adipose tissue macrophages in male obese mice
Quantitative analysis of immunoblots was performed (F’). G-G’. Splicing of XBP1 mRNA was analyzed from eWAT of DIO mice treated with vehicle or STF by RT-PCR and resolved by agarose gel ...
Frontiers1d
A new strategy for the treatment of advanced ovarian cancer: utilizing nanotechnology to regulate the tumor microenvironment
TLR agonists can bind to TLRs on the surface of TAMs ... KIRA6 is an advanced small molecule IRE1α kinase and RNase inhibitor that reduces the synthesis of FAs through XBP1. α-Tocopherol relieves ...