RNA splicing is a modification of the nascent pre-messenger RNA (pre-mRNA) transcript in which introns are removed and exons are joined prior to translation. For many eukaryotic introns ...

Mesoscale eddies play an important role in ocean energy and material transport. However, the effect of eddies on bacterial and eukaryotic community and their ecological effects remains unclear, ...

In silico tools for splicing defect prediction have a key role to assess the impact of variants of uncertain significance. Our aim was to evaluate the performance of a set of commonly used splicing in ...

The complexity of eukaryotic DNA, with its long-range interactions ... The model demonstrated sensitivity to mutations in start codons, splice sites, and conserved genomic regions, with ...

RNA splicing is an essential part of eukaryotic gene expression. Although the mechanism of splicing has been extensively studied in vitro, in vivo kinetics for the two-step splicing reaction remain ...

Here, we report widespread changes in alternative splicing of pre-mRNA in the flow-activated murine arterial endothelium in vivo. Alternative splicing was suppressed by depletion of platelets and ...