RNA splicing is a modification of the nascent pre-messenger RNA (pre-mRNA) transcript in which introns are removed and exons are joined prior to translation. For many eukaryotic introns ...

Researchers at the Arc Institute, Stanford University, and NVIDIA have developed Evo 2, an advanced AI model capable of predicting genetic variations and generating genomic sequences across all ...

Organelles are entities within a eukaryotic cell that have a specialised ... Here, the authors characterize a primate-specific splice isoform, Nedd4-1(NE), that is localized to late endosomes ...

In higher eukaryotes, a vast variety of RNAs are transcribed from genomic DNAs. The transcribed RNAs are subjected to RNA splicing in order to produce mRNAs and non-coding RNAs. Splicing includes ...

Dr. Yagi said, “BTB’s focus on novel non-opioid therapies and novel RNA splicing modifiers resonates with our investment thesis to bring innovative therapeutics in the areas of significant ...

In silico tools for splicing defect prediction have a key role to assess the impact of variants of uncertain significance. Our aim was to evaluate the performance of a set of commonly used splicing in ...

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This important work is a versatile new addition to the chemical protein modifications and bioconjugation toolbox in synthetic biology. The technology developed cleverly uses Connectase to irreversibly ...