The game also brought back the timed completion challenges from the first game, with special unlockable weapons for completing the game in under two and a half hours and completing it without saving. Getting an A-Rank run in under two and a half hours is one of the tougher Resident Evil challenges, and getting 100% of the unlocks can take a while.

The upcoming Resident Evil movie from Barbarian director Zach Cregger was confirmed to be unlike previous films in the franchise.