Heidelberg biochemists and structural biologists from Shanghai unravel the roles of two key regulatory factors in mRNA ...

Scientists found that pseudouridine helps small RNAs pass on traits and avoid immune detection, offering clues for future RNA ...

Scientists at Oak Ridge National Laboratory have developed the first-ever method of detecting ribonucleic acid, or RNA, ...

Two molecular control factors play a decisive role in what is known as splicing, the cutting and assembly of mature messenger ...

This month's cover highlights the article Immune cells adapt to confined environments in vivo to optimise nuclear plasticity for migration by Helen Weavers and Tua Karling. The cover features confocal ...

Emerging evidence suggests that some variants, which are described as missense, synonymous or nonsense variants in the literature or databases, may be deleterious by affecting the pre-mRNA splicing ...

Researchers have discovered that cancer cells suppress 'poison exons' -- genetic elements that act as an off switch for protein production -- in a key gene called TRA2 , promoting tumor growth.

Protein arginine methyltransferases (PRMTs) are required for the regulation of RNA processing factors ... and SmD1 recapitulated splicing changes seen with Type II PRMT inhibition, without disrupting ...

These findings are consistent with evolutionary pressure for donor sequences optimized for fast splicing. After donor site recognition by U1 snRNP, the Prp28 RNA helicase mediates the exchange of U1 ...

Our aim was to evaluate the performance of a set of commonly used splicing in silico tools comparing the predictions against RNA in vitro results. This was done for natural splice sites of clinically ...