eLife2d
Generative modeling for RNA splicing predictions and design
Alternative splicing (AS) of pre-mRNA plays a crucial role in tissue-specific gene regulation, with disease implications due to splicing defects. Predicting and manipulating AS can therefore uncover ...
Nature11d
RNA splicing articles from across Nature Portfolio
RNA splicing is a modification of the nascent pre-messenger RNA (pre-mRNA) transcript in which introns are removed and exons are joined prior to translation. For many eukaryotic introns ...
First clinical RNA sequencing test promises enhanced genetic diagnostics
RNA sequencing has emerged as a powerful supplement to DNA sequencing for Mendelian disease diagnosis, but clinical translation of diagnostic RNA-seq has not been widely achieved. Researchers at ...
AZoLifeSciences on MSN4d
New Discovery in RNA Splicing Could Transform Treatment of Aggressive Cancers
Alternative RNA splicing is like a movie editor cutting and rearranging scenes from the same footage to create different ...
Baylor College of Medicine17d
Baylor researchers develop and validate clinical diagnostic RNA sequencing test
RNA sequencing has emerged as a powerful supplement to DNA sequencing for Mendelian disease diagnosis, but clinical translation of diagnostic RNA-seq ...
Phys.org26d
Computational solution to model 3D RNA structures could speed medical discoveries by decades
Get Instant Summarized Text (Gist) A computational tool named NuFold has been developed to model 3D RNA structures, potentially accelerating medical discoveries by decades. This tool addresses the ...
Business Wire25d
Industry Veteran and VC Investor Strengthen the BTB Therapeutics Board
Dr. Yagi said, “BTB’s focus on novel non-opioid therapies and novel RNA splicing modifiers resonates with our investment thesis to bring innovative therapeutics in the areas of significant ...
The EMBO Journal24d
Cytosolic CRISPR RNAs for efficient application of RNA-targeting CRISPR-Cas systems
In particular, RNA-targeting CRISPR-Cas13 proteins are promising single-effector systems to regulate target mRNAs without altering genomic DNA, yet the current Cas13 systems are restrained by ...
The EMBO Journal24d
Cytosolic CRISPR RNAs for efficient application of RNA-targeting CRISPR-Cas systems
This month's cover highlights the article Immune cells adapt to confined environments in vivo to optimise nuclear plasticity for migration by Helen Weavers and Tua Karling. The cover features confocal ...
Frontiers18d
Computational Tools for Splicing Defect Prediction in Breast/Ovarian Cancer Genes: How Efficient Are They at Predicting RNA Alterations?
Our aim was to evaluate the performance of a set of commonly used splicing in silico tools comparing the predictions against RNA in vitro results. This was done for natural splice sites of clinically ...
C&EN28d
NABhClassifier Server: A Tool for the Identification of Helical Nucleic Acid-Binding Sequences in Proteins
NABPs typically contain at least one DNA or RNA-binding domain, where interactions with amino acids occur in either specific or nonspecific manner. (3,4) These proteins are generally classified into ...