Pulmonary arterial hypertension (PAH), defined as a mean ... and may lead to right-heart failure and death. The pathogenesis of PAH is complex and incompletely understood, but includes both ...

cholesterol the role of natriuretic peptide signaling and mineralocorticoid receptor antagonism in protecting against adverse remodeling in the pressure-overloaded heart the molecular pathogenesis of ...

In pulmonary hypertension, a combination of metabolic and mechanical dysfunction leads to irreversible vascular damage.

Pulmonary arterial hypertension (PAH) is a rare and severe lung disease with a life-threatening prognosis. After several positive trials, a recent study has confirmed the efficacy of a biotherapy, ...

Mendelian randomization (MR) represents a valuable methodology to address the causal relationships between an exposure and an ...

The 6th World Symposium on Pulmonary Hypertension Task Force on hemodynamic ... into 5 diagnostic categories by shared pathobiology and pathophysiology. 3 This extensive testing, which is required ...