Changes in the expression and prognostic significance of myofibroblast-like cancer-associated fibroblasts (myCAFs) markers across different types of tumors. Red indicates increased expression of the ...

The cells in human bodies are subject to both chemical and mechanical forces. But until recently, scientists have not ...

To the scientists' surprise, it is structural cells called reticular fibroblasts, present in the lymph nodes, that have the essential task of providing the ligand for the NOTCH signal, in order to ...

lung tissue demonstrating that Piezo2 (brown staining) is strongly present in areas of fibrosis. Bottom: Blockade of Piezo2 expression reduces fibrotic programming of lung fibroblasts. Human lung ...

Fibrosis is an affliction wherein cells produce excess fibrous tissue. Fibroblast cells do this to close wounds, but the process can cascade in unwanted places. Examples include cardiac fibrosis; ...

Piezo2 is highly expressed in human lung tissue from patients with IPF and in multiple (different) mouse models of lung fibrosis. Piezo2 is highly expressed in primary human lung fibroblasts in ...

Research on this issue has mostly relied on real organs, making it difficult to study the detailed interaction between blood flow and tissue during an erection. In a recent study published in ...

Biomedical researchers at Washington University in St. Louis have decoded how mechanical forces drive cell behavior in fibrosis.