Frontiers28d
Metabolic Reprograming of Cystic Fibrosis Macrophages via the IRE1α Arm of the Unfolded Protein Response Results in Exacerbated Inflammation
XBP1 mRNA splicing was detected by reverse transcription (RT)-PCR ... After activation, the supernatants were collected for cytokine detection, cells were washed twice and media was changed for ...
eLife14d
The ALS-associated co-chaperone DNAJC7 mediates neuroprotection against proteotoxic stress by modulating HSF1 activity
The Ken & Ruth Davee Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, United States Simpson Querrey Institute, Northwestern University, Chicago, United States ...
gut.bmj2d
PHLDA3 overexpression in hepatocytes by endoplasmic reticulum stress via IRE1–Xbp1s pathway expedites liver injury
Treatment of mice with tunicamycin (Tm) (an ER stress inducer) increased PHLDA3 expression in the liver. X box-binding protein-1 (Xbp1) was newly identified as a transcription factor responsible for ...
Frontiers23d
Role of endoplasmic reticulum stress in cell apoptosis induced by duck hepatitis A virus type 1 infection
1 College of Veterinary Medicine, Shandong Agricultural University, Taian, Shandong, China 2 Shandong Provincial Key Laboratory of Zoonoses, Shandong Agricultural University, Tai'an, Shandong, China ...
eLife23d
Targeting IRE1α improves insulin sensitivity and thermogenesis and suppresses metabolically active adipose tissue macrophages in male obese mice
Quantitative analysis of immunoblots was performed (F’). G-G’. Splicing of XBP1 mRNA was analyzed from eWAT of DIO mice treated with vehicle or STF by RT-PCR and resolved by agarose gel ...
imdb.com20d
Splice: Why The Sci-Fi Horror Movie's Sequel Never Happened
IMDb.com, Inc. takes no responsibility for the content or accuracy of the above news articles, Tweets, or blog posts. This content is published for the entertainment of our users only. The news ...
The EMBO Journal23d
Chaperone-mediated autophagy regulates the metastatic state of mesenchymal tumors
Combined, these findings show that CMA displays a broad targetability on multiple steps of the EMT process and indicate a substantial role of CMA in regulating the stability of pro-metastatic and ...